- Original Article
- Human Surfactant Protein-A(SP-A) Gene Locus Associated with Mycoplasma pneumoniae Pneumonia in Korean Children
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Seung Soo Kim, In Kyu Lee, Jung Ho Ko, Myung Ho Oh, Chong Woo Bae
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Clin Exp Pediatr. 2005;48(4):376-379. Published online April 15, 2005
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Purpose : Mycoplasama pneumoniae is a leading cause of pneumonia and exacerbates other respiratory conditions such as asthma. Surfactant protein A(SP-A) is involved in surfactant physiology and surfactant structure, and plays a major role in innate host defense and inflammatory processes in the lung. In this study, SP-A mediated mycoplasma cidal activity. The candidate-gene approach was used to study the... |
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- Assessment of Cardiac Function in Neonates by Using Tissue Doppler Imaging
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Hee Chul Yoon, Jae Hoon Choe, Sun Young Kim, In Kyu Lee, Myung Ho Oh
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Clin Exp Pediatr. 2004;47(9):959-964. Published online September 15, 2004
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Purpose : Tissue Doppler imaging(TDI) is recently being used for assessement of regional ventricular function in adults. However, data in neonates have not been established yet. The aim of this study is to establish reference values of TDI velocities and to investigate the effect of other factors on TDI velocites in the neonatal population.
Methods : Forty eight healthy neonates with... |
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- Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Respiratory Distress Syndrome in Korean Neonates
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Jae Hoon Choe, Myung Ho Oh, Jung Ho Ko, Sun Young Kim, In Kyu Lee, Chong Woo Bae
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Clin Exp Pediatr. 2004;47(7):735-739. Published online July 15, 2004
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Purpose : Respiratory distress syndrome(RDS) is caused by a deficiency of pulmonary surfactant, which is a lipoprotein complex. Both low levels of surfactant protein A(SP-A) and SP-A alleles have been associated with RDS. However, the genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the SP-A gene locus and RDS in... |
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- Differential Response of Surfactant Protein-A Genetic Variants to Dexamethasone Treatment
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Eul Soon Kim, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
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Clin Exp Pediatr. 2003;46(4):335-339. Published online April 15, 2003
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Purpose : Surfactant protein A(SP-A) is involved in surfactant physiology and structure, and plays a major role in innate host defense and inflammatory processes in the lung. Steroid therapy is widely used for mothers who threaten to deliver prematurely and also used commonly in the management of preterm infants with chronic lung disease. Two SP-A genes(SP-A1, SP-A2) and several alleles... |
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- Allele Distribution and Frequency of Human Surfactant
Protein-A2 in Korean Neonates
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Nyeon Cheon Kim, Hee Chul Yoon, Jung Su Suk, Jung Ho Ko, Ook Joon Yoo, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
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Clin Exp Pediatr. 2003;46(4):340-344. Published online April 15, 2003
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Purpose : We evaluated allele frequencies and distribution of surfactant protein A2(SP-A2) in Korean neonates in order to estimate the prevalence of RDS, to find out new SP-A alleles, and to establish new steroid therapy.
Methods : Genomic DNA was extracted from 71 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations... |
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- Allele Distribution and Frequency of Human Surfactant
Protein-A1 in Korean Neonates
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Kyung Shin Lee, Young Hee Kim, Jung Su Suk, Jung Ho Ko, Ook Joon Yoo, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
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Clin Exp Pediatr. 2002;45(12):1497-1502. Published online December 15, 2002
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Purpose : We evaluated allele frequencies and distribution of surfactant protein A1(SP-A1) in Korean neonates in order to estimate prevalence of RDS to find out new SP-A alleles, and to establish new steroid therapy.
Methods : Genomic DNA was extracted from 100 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were... |
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- Significance of Acute Phase Reactants(APR) Score for the Early Detection of Neonatal Bacterial Infection
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Seong Woo Kim, Myung Ho Oh, Kee Hyuk Kim, Jay G. Sim
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Clin Exp Pediatr. 1998;41(11):1491-1497. Published online November 15, 1998
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Purpose : We performed acute phase reactants(APR) test to evaluate as an appropriate screening test for the early detection of neonatal bacterial infection.
Methods : We selected 174 neonates and divided into two groups; sepsis group and well-baby group. We performed APR test.
Results : There are no significant difference in total leukocyte count, immature to mature rentrophil ratio, toxic granules, and... |
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- Cold Agglutinin and Mycoplasma Antibody Titersin Children with Mycoplasma pneumoniae Pneumonia During Recent 5 Years
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Seon Hwa Yoon, Joon Kyo Jung, Myung Ho Oh
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Clin Exp Pediatr. 1996;39(7):943-952. Published online July 15, 1996
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Purpose : More effective diagnosis and treatment through a survey on clinical aspect for the
last 5 years and interrelation between cold agglutinin titer and mycoplasma antibody titer of
Mycoplasma pneumoniae pneumonia.
Methods : 369 patients hospitalized in the department of pediatrics of Chung Goo Sung Shim
Hospital for the 5 years from January 1990 to December 1994 have been surveyed, which
diagnosed to be... |
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- A Case of Medistinal Lipoma.
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Hung Sub Choi, Myung Ho Oh, Chang Hwi Kim, Sang Jhoo Lee, Yong Sik Lee
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Clin Exp Pediatr. 1988;31(1):141-146. Published online January 31, 1988
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The mediastinal lipoma is a rare benign tumor.
Since the original description by Fothergill in 1781, about 120 cases have been reported in literature.
Of these, less than ten have been reported in children below the age of twelve.
We experienced a case of mediastinal lipoma, in a 5 year old girl with mild dry cough. Chest X-ray
showed a large, homogeneous soft tissue... |
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- A Clinical Studey on Reye Syndrome.
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Myung Ho Oh, Hung Sub Choi, Chang Hwi Kim, Sang Jhoo Lee
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Clin Exp Pediatr. 1987;30(11):1243-1251. Published online November 30, 1987
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We took clinical study for 47 cases of Reye syndrome at S.C.H. University Hospital during last 8
years from Jan:, 1979 to Dec., 1986.
The results obtained were as follows;
1) There was no significant difference in annual incidence and the seasonal incidence was highest
in sumer and autumn.
2) The sex ratio of male to female was... |
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